Drug interactions
Imipramine + Isoproterenol
Severity: Moderate
Imipramine and Isoproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can modify responses to sympathomimetics. Because isoproterenol is a direct beta agonist not dependent on neuronal uptake, the effect is less pronounced than with norepinephrine, but tachycardia and arrhythmias may be more likely in patients on a tricyclic, which has its own cardiac effects.
What this interaction means in plain words
Imipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Isoproterenol belongs to Respiratory.
Why it happens
Tricyclic-induced alterations in adrenergic neuronal reuptake and additive cardiac effects; direct beta agonism is largely unaffected by reuptake blockade.
What to do
Monitor heart rate, blood pressure and ECG when isoproterenol is given to a patient on imipramine, and titrate the isoproterenol dose cautiously.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Isoproterenol
Frequently asked questions
Can I take Imipramine with Isoproterenol?
MediHelp rates the interaction as moderate. Imipramine and Isoproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can modify responses to sympathomimetics. Because isoproterenol is a direct beta agonist not dependent on neuronal uptake, the effect is less pronounced than with norepinephrine, but tachycardia and arrhythmias may be more likely in patients on a tricyclic, which has its own cardiac effects.
How serious is the interaction between Imipramine and Isoproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG when isoproterenol is given to a patient on imipramine, and titrate the isoproterenol dose cautiously.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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