Drug interactions
Imipramine + Lemborexant
Severity: Moderate
Imipramine and Lemborexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lemborexant and imipramine both cause sedation, so their combination can intensify drowsiness and impair next-day alertness and coordination. Falls and driving impairment are the main practical concerns.
What this interaction means in plain words
Imipramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Lemborexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and the sedating properties of imipramine.
What to do
Use the lowest effective lemborexant dose and monitor for daytime somnolence. Warn the patient about driving and other hazardous activities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Imipramine with Lemborexant?
MediHelp rates the interaction as moderate. Imipramine and Lemborexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lemborexant and imipramine both cause sedation, so their combination can intensify drowsiness and impair next-day alertness and coordination. Falls and driving impairment are the main practical concerns.
How serious is the interaction between Imipramine and Lemborexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lemborexant dose and monitor for daytime somnolence. Warn the patient about driving and other hazardous activities.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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