Drug interactions
Imipramine + Linagliptin-metformin
Severity: Minor
Imipramine and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance glucose lowering and in some patients alter glycemic control, sometimes causing hypoglycemia. The effect is generally small with metformin, which rarely causes hypoglycemia on its own.
What this interaction means in plain words
Imipramine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Linagliptin-metformin belongs to Endocrine.
Why it happens
Proposed additive effects on glucose metabolism and insulin sensitivity; the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the antidepressant and adjust therapy if glucose changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Linagliptin-metformin?
MediHelp rates the interaction as minor. Imipramine and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may enhance glucose lowering and in some patients alter glycemic control, sometimes causing hypoglycemia. The effect is generally small with metformin, which rarely causes hypoglycemia on its own.
How serious is the interaction between Imipramine and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the antidepressant and adjust therapy if glucose changes.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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