Drug interactions
Imipramine + Loxapine
Severity: Moderate
Imipramine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the CNS and have anticholinergic activity, so together they can cause greater drowsiness, confusion, dry mouth and urinary retention. Loxapine may also raise tricyclic concentrations and lower seizure threshold.
What this interaction means in plain words
Imipramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects, with possible CYP2D6 competition.
What to do
Monitor sedation, anticholinergic effects and seizure risk, and start with low doses. Reduce imipramine dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Imipramine with Loxapine?
MediHelp rates the interaction as moderate. Imipramine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the CNS and have anticholinergic activity, so together they can cause greater drowsiness, confusion, dry mouth and urinary retention. Loxapine may also raise tricyclic concentrations and lower seizure threshold.
How serious is the interaction between Imipramine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, anticholinergic effects and seizure risk, and start with low doses. Reduce imipramine dose if signs of toxicity appear.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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