Drug interactions
Imipramine + Metaxalone
Severity: Moderate
Imipramine and Metaxalone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a tricyclic antidepressant with sedative and anticholinergic properties, and it may add to metaxalone-related drowsiness. Serotonergic effects have also been reported with metaxalone, so rare serotonin toxicity is theoretically possible.
What this interaction means in plain words
Imipramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Metaxalone belongs to Musculoskeletal.
Why it happens
Additive central nervous system depression; possible weak additive serotonergic effects.
What to do
Monitor for oversedation, and for agitation, tremor or hyperthermia suggesting serotonin toxicity. Counsel on driving and adjust doses if impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metaxalone
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Metaxalone?
MediHelp rates the interaction as moderate. Imipramine and Metaxalone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a tricyclic antidepressant with sedative and anticholinergic properties, and it may add to metaxalone-related drowsiness. Serotonergic effects have also been reported with metaxalone, so rare serotonin toxicity is theoretically possible.
How serious is the interaction between Imipramine and Metaxalone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, and for agitation, tremor or hyperthermia suggesting serotonin toxicity. Counsel on driving and adjust doses if impairment occurs.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
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