Drug interactions
Imipramine + Methocarbamol
Severity: Moderate
Imipramine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a sedating tricyclic antidepressant with anticholinergic effects. Combined with methocarbamol it can increase drowsiness and psychomotor impairment, and confusion or falls in older patients.
What this interaction means in plain words
Imipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects of a tricyclic antidepressant and a centrally acting muscle relaxant.
What to do
Monitor for oversedation, confusion and falls. Reduce the dose of one agent if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Methocarbamol?
MediHelp rates the interaction as moderate. Imipramine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a sedating tricyclic antidepressant with anticholinergic effects. Combined with methocarbamol it can increase drowsiness and psychomotor impairment, and confusion or falls in older patients.
How serious is the interaction between Imipramine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, confusion and falls. Reduce the dose of one agent if sedation is excessive.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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