Drug interactions
Imipramine + Nalbuphine
Severity: Moderate
Imipramine and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a sedating tricyclic antidepressant, so use with nalbuphine can increase drowsiness and CNS depression. Anticholinergic effects may add to confusion in older patients.
What this interaction means in plain words
Imipramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid activity and tricyclic antidepressant sedative properties.
What to do
Start nalbuphine at a low dose and titrate with monitoring of sedation and respiration. Counsel patients on avoiding driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Nalbuphine?
MediHelp rates the interaction as moderate. Imipramine and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a sedating tricyclic antidepressant, so use with nalbuphine can increase drowsiness and CNS depression. Anticholinergic effects may add to confusion in older patients.
How serious is the interaction between Imipramine and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nalbuphine at a low dose and titrate with monitoring of sedation and respiration. Counsel patients on avoiding driving.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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