Drug interactions
Imipramine + Oliceridine
Severity: Major
Imipramine and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine inhibits CYP2D6 to some extent, which may raise oliceridine exposure, and both drugs depress the CNS. Opioids with serotonergic tricyclics also carry a risk of serotonin toxicity.
What this interaction means in plain words
Imipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Imipramine belongs to Central Nervous System; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, partial CYP2D6 inhibition by imipramine, and additive serotonergic effects.
What to do
Use the lowest effective oliceridine dose and monitor for sedation, respiratory depression and serotonin toxicity. Re-titrate oliceridine if imipramine is stopped or started.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Imipramine with Oliceridine?
MediHelp rates the interaction as major. Imipramine and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Imipramine inhibits CYP2D6 to some extent, which may raise oliceridine exposure, and both drugs depress the CNS. Opioids with serotonergic tricyclics also carry a risk of serotonin toxicity.
How serious is the interaction between Imipramine and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective oliceridine dose and monitor for sedation, respiratory depression and serotonin toxicity. Re-titrate oliceridine if imipramine is stopped or started.
What other medicines interact with Imipramine?
MediHelp also lists interactions of Imipramine with, for example, Dronedarone, Isocarboxazid, Phenelzine. The full list is on the Imipramine page.
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