Drug interactions
Imipramine + Orphenadrin
Severity: Moderate
Imipramine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a tricyclic antidepressant with strong anticholinergic and sedative effects, which orphenadrine adds to. The combination can cause confusion, delirium, tachycardia, constipation, urinary retention and marked drowsiness.
What this interaction means in plain words
Imipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Avoid in elderly patients and those with glaucoma, prostatic hypertrophy or arrhythmia risk. Otherwise use the lowest doses and monitor for anticholinergic toxicity and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Orphenadrin?
MediHelp rates the interaction as moderate. Imipramine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a tricyclic antidepressant with strong anticholinergic and sedative effects, which orphenadrine adds to. The combination can cause confusion, delirium, tachycardia, constipation, urinary retention and marked drowsiness.
How serious is the interaction between Imipramine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in elderly patients and those with glaucoma, prostatic hypertrophy or arrhythmia risk. Otherwise use the lowest doses and monitor for anticholinergic toxicity and sedation.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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