Drug interactions
Imipramine + Oxymorphone
Severity: Moderate
Imipramine and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combined use can increase drowsiness, psychomotor impairment and respiratory depression. Tricyclic anticholinergic effects may add to opioid-related constipation and urinary retention.
What this interaction means in plain words
Imipramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid receptor agonism and tricyclic sedative and anticholinergic activity.
What to do
Start with the lowest effective doses and titrate slowly while monitoring sedation and respiratory rate. Warn patients against driving or using machinery until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Oxymorphone?
MediHelp rates the interaction as moderate. Imipramine and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combined use can increase drowsiness, psychomotor impairment and respiratory depression. Tricyclic anticholinergic effects may add to opioid-related constipation and urinary retention.
How serious is the interaction between Imipramine and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective doses and titrate slowly while monitoring sedation and respiratory rate. Warn patients against driving or using machinery until the response is known.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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