Drug interactions
Imipramine + Pancuronium
Severity: Moderate
Imipramine and Pancuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pancuronium has vagolytic and sympathomimetic properties, and tricyclic antidepressants impair catecholamine reuptake and are proarrhythmic. Combined use has been associated with tachyarrhythmias and hypertension during anesthesia.
What this interaction means in plain words
Imipramine and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Pancuronium belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effects: pancuronium vagolysis and norepinephrine release with tricyclic inhibition of catecholamine reuptake.
What to do
Monitor ECG and blood pressure during anesthesia. Consider a blocker with less cardiovascular stimulation if arrhythmia risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pancuronium
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Pancuronium?
MediHelp rates the interaction as moderate. Imipramine and Pancuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pancuronium has vagolytic and sympathomimetic properties, and tricyclic antidepressants impair catecholamine reuptake and are proarrhythmic. Combined use has been associated with tachyarrhythmias and hypertension during anesthesia.
How serious is the interaction between Imipramine and Pancuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and blood pressure during anesthesia. Consider a blocker with less cardiovascular stimulation if arrhythmia risk is high.
What other medicines interact with Pancuronium?
MediHelp also lists interactions of Pancuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Pancuronium page.
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