Drug interactions
Imipramine + Saxagliptin-metformin
Severity: Minor
Imipramine and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with altered glycemic control, and additive glucose lowering with antidiabetic drugs is possible. The effect is inconsistent and usually of limited clinical importance.
What this interaction means in plain words
Imipramine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
The mechanism is not well established; tricyclics may alter insulin secretion or sensitivity and affect appetite and weight.
What to do
No routine change is needed; check glucose if the patient reports symptoms of hypoglycemia or hyperglycemia after starting imipramine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Imipramine and Saxagliptin-metformin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Saxagliptin-metformin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Imipramine and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with altered glycemic control, and additive glucose lowering with antidiabetic drugs is possible. The effect is inconsistent and usually of limited clinical importance.
How serious is the interaction between Imipramine and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; check glucose if the patient reports symptoms of hypoglycemia or hyperglycemia after starting imipramine.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
