Drug interactions
Imipramine + Tamsulosin
Severity: Moderate
Imipramine and Tamsulosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is a weak CYP2D6 inhibitor and a CYP2D6 substrate, so competitive effects may modestly increase tamsulosin levels. Both agents can cause orthostatic hypotension, which may be additive.
What this interaction means in plain words
Imipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Imipramine belongs to Central Nervous System; Tamsulosin belongs to Genitourinary.
Why it happens
Imipramine competes for CYP2D6 metabolism and has additive alpha-blocking and hypotensive effects.
What to do
Monitor for orthostatic hypotension and dizziness, especially in older adults. Lower the tamsulosin dose if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tamsulosin
- Alfuzosin + Tamsulosin Major
- Avanafil + Tamsulosin Major
- Ceritinib + Tamsulosin Major
- Clarithromycin + Tamsulosin Major
- Cobicistat + Tamsulosin Major
- Doxazosin + Tamsulosin Major
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Tamsulosin?
MediHelp rates the interaction as moderate. Imipramine and Tamsulosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imipramine is a weak CYP2D6 inhibitor and a CYP2D6 substrate, so competitive effects may modestly increase tamsulosin levels. Both agents can cause orthostatic hypotension, which may be additive.
How serious is the interaction between Imipramine and Tamsulosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension and dizziness, especially in older adults. Lower the tamsulosin dose if symptoms develop.
What other medicines interact with Tamsulosin?
MediHelp also lists interactions of Tamsulosin with, for example, Alfuzosin, Avanafil, Ceritinib. The full list is on the Tamsulosin page.
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