Drug interactions
Imipramine + Zafirlukast
Severity: Minor
Imipramine and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imipramine is metabolized by several CYP enzymes including CYP3A4, which zafirlukast may weakly inhibit. Clinically significant tricyclic accumulation is not expected.
What this interaction means in plain words
Imipramine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Imipramine belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP3A4-mediated imipramine metabolism by zafirlukast.
What to do
No routine adjustment is needed. Watch for anticholinergic effects or sedation if symptoms emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Imipramine with Zafirlukast?
MediHelp rates the interaction as minor. Imipramine and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Imipramine is metabolized by several CYP enzymes including CYP3A4, which zafirlukast may weakly inhibit. Clinically significant tricyclic accumulation is not expected.
How serious is the interaction between Imipramine and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Watch for anticholinergic effects or sedation if symptoms emerge.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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