Drug interactions
Incobotulinumtoxina + Succinylcholine
Severity: Moderate
Incobotulinumtoxina and Succinylcholine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Neuromuscular blockers can add to the effect of botulinum toxin and cause excessive muscle weakness. This could include swallowing or breathing difficulty if the toxin has spread beyond the injection site. The risk with a single dose of succinylcholine is small, though it is higher in patients who recently received toxin.
What this interaction means in plain words
Incobotulinumtoxina and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of neuromuscular transmission: the toxin blocks presynaptic acetylcholine release and succinylcholine depolarizes the endplate.
What to do
Tell the anesthesia team about recent toxin injections. Titrate neuromuscular blockers and monitor respiratory function and neuromuscular recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Succinylcholine
Frequently asked questions
Can I take Incobotulinumtoxina with Succinylcholine?
MediHelp rates the interaction as moderate. Incobotulinumtoxina and Succinylcholine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Neuromuscular blockers can add to the effect of botulinum toxin and cause excessive muscle weakness. This could include swallowing or breathing difficulty if the toxin has spread beyond the injection site. The risk with a single dose of succinylcholine is small, though it is higher in patients who recently received toxin.
How serious is the interaction between Incobotulinumtoxina and Succinylcholine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about recent toxin injections. Titrate neuromuscular blockers and monitor respiratory function and neuromuscular recovery.
What other medicines interact with Succinylcholine?
MediHelp also lists interactions of Succinylcholine with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Succinylcholine page.
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