Drug interactions
Indacaterol-glycopyrronium + Lofepramine
Severity: Moderate
Indacaterol-glycopyrronium and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant with anticholinergic activity. With inhaled glycopyrronium it can cause additive dry mouth, constipation, urinary retention and blurred vision.
What this interaction means in plain words
Indacaterol-glycopyrronium and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects, particularly in older patients or those with glaucoma or prostatic hypertrophy. Adjust therapy if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Lofepramine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lofepramine is a tricyclic antidepressant with anticholinergic activity. With inhaled glycopyrronium it can cause additive dry mouth, constipation, urinary retention and blurred vision.
How serious is the interaction between Indacaterol-glycopyrronium and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, particularly in older patients or those with glaucoma or prostatic hypertrophy. Adjust therapy if symptoms occur.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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