Drug interactions
Indacaterol-glycopyrronium + Lumefantrine
Severity: Moderate
Indacaterol-glycopyrronium and Lumefantrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumefantrine, in artemether-lumefantrine, can prolong the QT interval. Indacaterol may add to proarrhythmic risk through beta-agonist effects and hypokalaemia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarisation.
What to do
Check ECG and correct potassium and magnesium before and during antimalarial therapy in patients with cardiac risk factors. Monitor for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Lumefantrine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Lumefantrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumefantrine, in artemether-lumefantrine, can prolong the QT interval. Indacaterol may add to proarrhythmic risk through beta-agonist effects and hypokalaemia.
How serious is the interaction between Indacaterol-glycopyrronium and Lumefantrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before and during antimalarial therapy in patients with cardiac risk factors. Monitor for palpitations or syncope.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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