Drug interactions
Indacaterol-glycopyrronium + Methyclothiazide
Severity: Moderate
Indacaterol-glycopyrronium and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium, and beta-2 agonists such as indacaterol can shift potassium into cells. Together they may produce additive hypokalemia, which can predispose to arrhythmias, particularly in patients with heart disease or hypoxia.
What this interaction means in plain words
Indacaterol-glycopyrronium and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium lowering through renal potassium loss from the thiazide and beta-2 mediated intracellular potassium shift from indacaterol.
What to do
Check serum potassium at baseline and periodically during combined use, especially in patients with cardiac disease. Replace potassium or magnesium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Methyclothiazide?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower serum potassium, and beta-2 agonists such as indacaterol can shift potassium into cells. Together they may produce additive hypokalemia, which can predispose to arrhythmias, particularly in patients with heart disease or hypoxia.
How serious is the interaction between Indacaterol-glycopyrronium and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium at baseline and periodically during combined use, especially in patients with cardiac disease. Replace potassium or magnesium if levels fall.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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