Drug interactions
Indacaterol-glycopyrronium + Norepinephrine
Severity: Moderate
Indacaterol-glycopyrronium and Norepinephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Norepinephrine is a potent sympathomimetic and can add to the cardiovascular stimulation from indacaterol. This may cause greater increases in heart rate and blood pressure and raise the risk of arrhythmias.
What this interaction means in plain words
Indacaterol-glycopyrronium and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation of the cardiovascular system by a sympathomimetic and a beta-2 agonist.
What to do
Monitor blood pressure, heart rate and ECG when norepinephrine is given to a patient on indacaterol, and titrate the infusion to effect. Watch for arrhythmias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Norepinephrine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Norepinephrine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Norepinephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Norepinephrine is a potent sympathomimetic and can add to the cardiovascular stimulation from indacaterol. This may cause greater increases in heart rate and blood pressure and raise the risk of arrhythmias.
How serious is the interaction between Indacaterol-glycopyrronium and Norepinephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and ECG when norepinephrine is given to a patient on indacaterol, and titrate the infusion to effect. Watch for arrhythmias.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
