Drug interactions
Indacaterol-glycopyrronium + Olanzapine / samidorphan
Severity: Moderate
Indacaterol-glycopyrronium and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity, and glycopyrronium adds further antimuscarinic effect. The combination can increase constipation and reduced gut motility, as well as urinary retention and dry mouth. Serious gastrointestinal hypomotility is the main concern.
What this interaction means in plain words
Indacaterol-glycopyrronium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects of glycopyrronium and olanzapine.
What to do
Monitor bowel function and urinary symptoms, and treat constipation early. Reassess the need for the combination if significant hypomotility develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity, and glycopyrronium adds further antimuscarinic effect. The combination can increase constipation and reduced gut motility, as well as urinary retention and dry mouth. Serious gastrointestinal hypomotility is the main concern.
How serious is the interaction between Indacaterol-glycopyrronium and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor bowel function and urinary symptoms, and treat constipation early. Reassess the need for the combination if significant hypomotility develops.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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