Drug interactions
Indacaterol-glycopyrronium + Olanzapine
Severity: Moderate
Indacaterol-glycopyrronium and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine has anticholinergic activity that can add to inhaled glycopyrronium, raising the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. Beta-2 agonists such as indacaterol may also slightly add to QT effects of antipsychotics.
What this interaction means in plain words
Indacaterol-glycopyrronium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Olanzapine belongs to Central Nervous System.
Why it happens
Additive antimuscarinic effects, plus possible minor additive QT prolongation and hypokalemia from the beta-2 agonist.
What to do
Monitor for anticholinergic effects, especially in older patients or those with glaucoma, prostatic hypertrophy or ileus. Check ECG and potassium if other QT-prolonging risk factors are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Olanzapine
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Olanzapine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine has anticholinergic activity that can add to inhaled glycopyrronium, raising the risk of dry mouth, constipation, urinary retention, blurred vision and tachycardia. Beta-2 agonists such as indacaterol may also slightly add to QT effects of antipsychotics.
How serious is the interaction between Indacaterol-glycopyrronium and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects, especially in older patients or those with glaucoma, prostatic hypertrophy or ileus. Check ECG and potassium if other QT-prolonging risk factors are present.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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