Drug interactions
Indacaterol-glycopyrronium + Olodaterol inhaled
Severity: Major
Indacaterol-glycopyrronium and Olodaterol inhaled: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are long-acting beta-2 agonists, so using them together duplicates therapy and increases the likelihood of tachycardia, tremor, hypokalemia and arrhythmias. The combination offers no recognised benefit over a single agent.
What this interaction means in plain words
Indacaterol-glycopyrronium and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta-2 adrenergic receptor stimulation from two long-acting beta-agonists.
What to do
Avoid concurrent use of two long-acting beta-agonists and use only one. If exposure has occurred, monitor heart rate, potassium and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Olodaterol inhaled?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are long-acting beta-2 agonists, so using them together duplicates therapy and increases the likelihood of tachycardia, tremor, hypokalemia and arrhythmias. The combination offers no recognised benefit over a single agent.
How serious is the interaction between Indacaterol-glycopyrronium and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists and use only one. If exposure has occurred, monitor heart rate, potassium and ECG.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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