Drug interactions
Indacaterol-glycopyrronium + Orphenadrine
Severity: Moderate
Indacaterol-glycopyrronium and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine has marked anticholinergic activity, which adds to the antimuscarinic effect of glycopyrronium. This can cause dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, especially in older adults.
What this interaction means in plain words
Indacaterol-glycopyrronium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity such as urinary retention, constipation and confusion. Use the lowest effective orphenadrine dose or choose a non-anticholinergic muscle relaxant in higher-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Orphenadrine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine has marked anticholinergic activity, which adds to the antimuscarinic effect of glycopyrronium. This can cause dry mouth, constipation, urinary retention, blurred vision, confusion and tachycardia, especially in older adults.
How serious is the interaction between Indacaterol-glycopyrronium and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity such as urinary retention, constipation and confusion. Use the lowest effective orphenadrine dose or choose a non-anticholinergic muscle relaxant in higher-risk patients.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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