Drug interactions
Indacaterol-glycopyrronium + Penbutolol
Severity: Major
Indacaterol-glycopyrronium and Penbutolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a non-selective beta-blocker that opposes the bronchodilator action of indacaterol and can provoke severe bronchospasm in patients with airway disease. The result may be reduced bronchodilator efficacy and worsened COPD or asthma control.
What this interaction means in plain words
Indacaterol-glycopyrronium and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism, with non-selective beta-blockade competing at beta-2 receptors.
What to do
Avoid non-selective beta-blockers in patients using indacaterol. If a beta-blocker is essential, choose a cardioselective agent and monitor respiratory function closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Penbutolol?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Penbutolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a non-selective beta-blocker that opposes the bronchodilator action of indacaterol and can provoke severe bronchospasm in patients with airway disease. The result may be reduced bronchodilator efficacy and worsened COPD or asthma control.
How serious is the interaction between Indacaterol-glycopyrronium and Penbutolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients using indacaterol. If a beta-blocker is essential, choose a cardioselective agent and monitor respiratory function closely.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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