Drug interactions
Indacaterol-glycopyrronium + Phenylephrine
Severity: Moderate
Indacaterol-glycopyrronium and Phenylephrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenylephrine is an alpha-adrenergic agonist whose cardiovascular effects, such as hypertension and reflex changes in heart rate, may combine with the sympathomimetic effects of indacaterol. Systemic phenylephrine (oral or injected) matters more than nasal or ophthalmic use.
What this interaction means in plain words
Indacaterol-glycopyrronium and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Phenylephrine belongs to Respiratory.
Why it happens
Additive sympathomimetic cardiovascular effects.
What to do
Monitor blood pressure, heart rate and palpitations when systemic phenylephrine is used. Prefer non-adrenergic decongestants in patients with cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Phenylephrine
- Isocarboxazid + Phenylephrine Contraindicated
- Phenelzine + Phenylephrine Contraindicated
- Phenylephrine + Tranylcypromine Contraindicated
- Bromocriptine + Phenylephrine Major
- Cocaine + Phenylephrine Major
- Dihydroergotamine intranasal + Phenylephrine Major
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Phenylephrine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Phenylephrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenylephrine is an alpha-adrenergic agonist whose cardiovascular effects, such as hypertension and reflex changes in heart rate, may combine with the sympathomimetic effects of indacaterol. Systemic phenylephrine (oral or injected) matters more than nasal or ophthalmic use.
How serious is the interaction between Indacaterol-glycopyrronium and Phenylephrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and palpitations when systemic phenylephrine is used. Prefer non-adrenergic decongestants in patients with cardiovascular disease.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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