Drug interactions
Indacaterol-glycopyrronium + Protriptyline
Severity: Major
Indacaterol-glycopyrronium and Protriptyline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that prolongs the QT interval and has strong anticholinergic effects. Together with indacaterol it may raise the risk of arrhythmia, and it adds to the antimuscarinic effects of glycopyrronium.
What this interaction means in plain words
Indacaterol-glycopyrronium and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, enhanced adrenergic cardiovascular effects, and additive antimuscarinic activity.
What to do
Monitor ECG, potassium and heart rhythm, and watch for anticholinergic effects such as urinary retention and constipation. Choose a less arrhythmogenic antidepressant if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Protriptyline?
MediHelp rates the interaction as major. Indacaterol-glycopyrronium and Protriptyline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Protriptyline is a tricyclic antidepressant that prolongs the QT interval and has strong anticholinergic effects. Together with indacaterol it may raise the risk of arrhythmia, and it adds to the antimuscarinic effects of glycopyrronium.
How serious is the interaction between Indacaterol-glycopyrronium and Protriptyline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and heart rhythm, and watch for anticholinergic effects such as urinary retention and constipation. Choose a less arrhythmogenic antidepressant if feasible.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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