Drug interactions
Indacaterol-glycopyrronium + Romidepsin
Severity: Moderate
Indacaterol-glycopyrronium and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin has been associated with ECG changes including QT prolongation. Together with indacaterol, which can lower potassium and stimulate the heart, the risk of ventricular arrhythmias may be higher.
What this interaction means in plain words
Indacaterol-glycopyrronium and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarisation, with beta-agonist related hypokalemia.
What to do
Monitor ECG, potassium and magnesium and correct deficits before and during romidepsin treatment. Reassess if QTc increases markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Romidepsin?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin has been associated with ECG changes including QT prolongation. Together with indacaterol, which can lower potassium and stimulate the heart, the risk of ventricular arrhythmias may be higher.
How serious is the interaction between Indacaterol-glycopyrronium and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium and correct deficits before and during romidepsin treatment. Reassess if QTc increases markedly.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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