Drug interactions
Indacaterol-glycopyrronium + Saquinavir
Severity: Moderate
Indacaterol-glycopyrronium and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir inhibits CYP3A4 and P-glycoprotein and may raise indacaterol levels. Saquinavir also prolongs the QT interval, so the combination can increase arrhythmic risk.
What this interaction means in plain words
Indacaterol-glycopyrronium and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein reduces indacaterol clearance, plus additive QT prolongation.
What to do
Obtain a baseline ECG and monitor QTc, potassium and magnesium. Watch for beta-agonist effects such as tachycardia and tremor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol-glycopyrronium and Saquinavir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Saquinavir?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir inhibits CYP3A4 and P-glycoprotein and may raise indacaterol levels. Saquinavir also prolongs the QT interval, so the combination can increase arrhythmic risk.
How serious is the interaction between Indacaterol-glycopyrronium and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc, potassium and magnesium. Watch for beta-agonist effects such as tachycardia and tremor.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
