Drug interactions
Indacaterol-glycopyrronium + Thiothixene
Severity: Moderate
Indacaterol-glycopyrronium and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiothixene is an antipsychotic with some QT-prolonging and anticholinergic effects. With indacaterol and glycopyrronium, the risk of arrhythmia and antimuscarinic adverse effects such as constipation and urinary retention may increase.
What this interaction means in plain words
Indacaterol-glycopyrronium and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and additive antimuscarinic effects.
What to do
Monitor ECG, potassium and magnesium, and watch for anticholinergic effects such as constipation and urinary retention. Adjust therapy if QTc prolongs or symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Thiothixene?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiothixene is an antipsychotic with some QT-prolonging and anticholinergic effects. With indacaterol and glycopyrronium, the risk of arrhythmia and antimuscarinic adverse effects such as constipation and urinary retention may increase.
How serious is the interaction between Indacaterol-glycopyrronium and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG, potassium and magnesium, and watch for anticholinergic effects such as constipation and urinary retention. Adjust therapy if QTc prolongs or symptoms develop.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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