Drug interactions
Indacaterol-glycopyrronium + Trifluoperazine
Severity: Moderate
Indacaterol-glycopyrronium and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trifluoperazine can prolong the QT interval and has anticholinergic activity, while indacaterol may add to arrhythmic risk and glycopyrronium adds anticholinergic effects. Together they may increase the risk of arrhythmia and anticholinergic effects such as dry mouth, urinary retention and constipation.
What this interaction means in plain words
Indacaterol-glycopyrronium and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and additive anticholinergic effects from combined antimuscarinic activity.
What to do
Monitor ECG and electrolytes in patients with cardiac risk factors. Watch for anticholinergic effects such as urinary retention, constipation and worsening of narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Trifluoperazine?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trifluoperazine can prolong the QT interval and has anticholinergic activity, while indacaterol may add to arrhythmic risk and glycopyrronium adds anticholinergic effects. Together they may increase the risk of arrhythmia and anticholinergic effects such as dry mouth, urinary retention and constipation.
How serious is the interaction between Indacaterol-glycopyrronium and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes in patients with cardiac risk factors. Watch for anticholinergic effects such as urinary retention, constipation and worsening of narrow-angle glaucoma.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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