Drug interactions
Indacaterol-glycopyrronium + Trihexyphenidyl
Severity: Moderate
Indacaterol-glycopyrronium and Trihexyphenidyl: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trihexyphenidyl is a strongly anticholinergic agent, and combined use with glycopyrronium may add to dry mouth, constipation, urinary retention, blurred vision and confusion. The effect is most relevant in older patients.
What this interaction means in plain words
Indacaterol-glycopyrronium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indacaterol-glycopyrronium belongs to Respiratory; Trihexyphenidyl belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor blockade.
What to do
Monitor for anticholinergic effects such as urinary retention, constipation and confusion. Reduce the trihexyphenidyl dose if effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Other interactions of Trihexyphenidyl
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Trihexyphenidyl?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Trihexyphenidyl can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trihexyphenidyl is a strongly anticholinergic agent, and combined use with glycopyrronium may add to dry mouth, constipation, urinary retention, blurred vision and confusion. The effect is most relevant in older patients.
How serious is the interaction between Indacaterol-glycopyrronium and Trihexyphenidyl?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention, constipation and confusion. Reduce the trihexyphenidyl dose if effects develop.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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