Drug interactions
Indacaterol-glycopyrronium + Trospium chloride
Severity: Moderate
Indacaterol-glycopyrronium and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both glycopyrronium and trospium are antimuscarinic agents. Using them together may increase anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, although inhaled glycopyrronium has low systemic exposure.
What this interaction means in plain words
Indacaterol-glycopyrronium and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic receptor blockade.
What to do
Avoid unnecessary duplication of antimuscarinics. If both are needed, monitor for urinary retention, constipation and glaucoma symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Trospium chloride?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both glycopyrronium and trospium are antimuscarinic agents. Using them together may increase anticholinergic effects such as dry mouth, constipation, urinary retention and blurred vision, although inhaled glycopyrronium has low systemic exposure.
How serious is the interaction between Indacaterol-glycopyrronium and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of antimuscarinics. If both are needed, monitor for urinary retention, constipation and glaucoma symptoms.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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