Drug interactions
Indacaterol-glycopyrronium + Umeclidinium bromide
Severity: Moderate
Indacaterol-glycopyrronium and Umeclidinium bromide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both products contain inhaled long-acting antimuscarinics, so combining them duplicates therapy. This increases anticholinergic adverse effects such as dry mouth, urinary retention and worsening glaucoma without clear added benefit.
What this interaction means in plain words
Indacaterol-glycopyrronium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Therapeutic duplication with additive muscarinic receptor antagonism.
What to do
Avoid using two long-acting antimuscarinics together; use only one. Review the inhaler regimen if the patient has both.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indacaterol-glycopyrronium
Frequently asked questions
Can I take Indacaterol-glycopyrronium with Umeclidinium bromide?
MediHelp rates the interaction as moderate. Indacaterol-glycopyrronium and Umeclidinium bromide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both products contain inhaled long-acting antimuscarinics, so combining them duplicates therapy. This increases anticholinergic adverse effects such as dry mouth, urinary retention and worsening glaucoma without clear added benefit.
How serious is the interaction between Indacaterol-glycopyrronium and Umeclidinium bromide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting antimuscarinics together; use only one. Review the inhaler regimen if the patient has both.
What other medicines interact with Indacaterol-glycopyrronium?
MediHelp also lists interactions of Indacaterol-glycopyrronium with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Indacaterol-glycopyrronium page.
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