Drug interactions
Indacaterol inhaled + Itraconazole
Severity: Moderate
Indacaterol inhaled and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may modestly increase systemic indacaterol exposure by inhibiting CYP3A4 and P-gp. Beta-agonist adverse effects such as tachycardia, tremor, hypokalemia and QT prolongation could be heightened, although studies show this is generally well tolerated at usual doses.
What this interaction means in plain words
Indacaterol inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing clearance of indacaterol, with possible additive QT effects.
What to do
Usual indacaterol doses are generally acceptable. Monitor heart rate, potassium and for palpitations, and obtain an ECG in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Itraconazole?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may modestly increase systemic indacaterol exposure by inhibiting CYP3A4 and P-gp. Beta-agonist adverse effects such as tachycardia, tremor, hypokalemia and QT prolongation could be heightened, although studies show this is generally well tolerated at usual doses.
How serious is the interaction between Indacaterol inhaled and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Usual indacaterol doses are generally acceptable. Monitor heart rate, potassium and for palpitations, and obtain an ECG in patients with QT risk factors.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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