Drug interactions
Indacaterol inhaled + Metoprolol
Severity: Moderate
Indacaterol inhaled and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers antagonize the bronchodilating effect of indacaterol and may provoke bronchospasm in patients with airway disease. Metoprolol is cardioselective but selectivity is dose dependent.
What this interaction means in plain words
Indacaterol inhaled and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-2 adrenergic receptors.
What to do
Avoid if possible; if a beta-blocker is required, use the lowest dose of a cardioselective agent and monitor respiratory symptoms and lung function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Indacaterol inhaled with Metoprolol?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers antagonize the bronchodilating effect of indacaterol and may provoke bronchospasm in patients with airway disease. Metoprolol is cardioselective but selectivity is dose dependent.
How serious is the interaction between Indacaterol inhaled and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if a beta-blocker is required, use the lowest dose of a cardioselective agent and monitor respiratory symptoms and lung function.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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