Drug interactions
Indacaterol inhaled + Paliperidone
Severity: Moderate
Indacaterol inhaled and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a beta-2 agonist, can cause QT prolongation and hypokalemia, and paliperidone also prolongs the QT interval. The combination may increase the risk of ventricular arrhythmia, though inhaled exposure is low.
What this interaction means in plain words
Indacaterol inhaled and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization; beta-2 agonist-related hypokalemia may add to the risk.
What to do
Check ECG and potassium in patients with cardiac risk factors. Use at the labeled indacaterol dose and watch for palpitations or syncope.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Indacaterol inhaled with Paliperidone?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a beta-2 agonist, can cause QT prolongation and hypokalemia, and paliperidone also prolongs the QT interval. The combination may increase the risk of ventricular arrhythmia, though inhaled exposure is low.
How serious is the interaction between Indacaterol inhaled and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and potassium in patients with cardiac risk factors. Use at the labeled indacaterol dose and watch for palpitations or syncope.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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