Drug interactions
Indacaterol inhaled + Perphenazine
Severity: Moderate
Indacaterol inhaled and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can prolong the QT interval and indacaterol, a beta-2 agonist, may also affect QTc and lower potassium. Together they may modestly increase the risk of ventricular arrhythmia, particularly with other risk factors.
What this interaction means in plain words
Indacaterol inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia and tachycardia as contributors.
What to do
Consider an ECG and check potassium in patients with cardiac disease or other QT-prolonging drugs. Report palpitations or syncope promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Indacaterol inhaled with Perphenazine?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine can prolong the QT interval and indacaterol, a beta-2 agonist, may also affect QTc and lower potassium. Together they may modestly increase the risk of ventricular arrhythmia, particularly with other risk factors.
How serious is the interaction between Indacaterol inhaled and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an ECG and check potassium in patients with cardiac disease or other QT-prolonging drugs. Report palpitations or syncope promptly.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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