Drug interactions
Indacaterol inhaled + Ribociclib
Severity: Moderate
Indacaterol inhaled and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib prolongs the QT interval and indacaterol, a beta-agonist, can also affect QTc and cause hypokalemia. Together they may add to arrhythmia risk, though inhaled systemic exposure is low.
What this interaction means in plain words
Indacaterol inhaled and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QTc prolongation.
What to do
Monitor ECG and serum potassium and magnesium when the two are used together. Correct electrolyte abnormalities and use the lowest effective indacaterol dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Ribociclib?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib prolongs the QT interval and indacaterol, a beta-agonist, can also affect QTc and cause hypokalemia. Together they may add to arrhythmia risk, though inhaled systemic exposure is low.
How serious is the interaction between Indacaterol inhaled and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium and magnesium when the two are used together. Correct electrolyte abnormalities and use the lowest effective indacaterol dose.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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