Drug interactions
Indacaterol inhaled + Tacrolimus
Severity: Minor
Indacaterol inhaled and Tacrolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus prolongs the QT interval and high systemic exposure to beta-2 agonists like indacaterol can also affect QTc and lower potassium. The combination may increase arrhythmia risk, though inhaled doses give limited systemic exposure.
What this interaction means in plain words
Indacaterol inhaled and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effect on QT interval, with beta-agonist related hypokalemia as a possible contributor.
What to do
No routine change is required at usual doses. Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Tacrolimus?
MediHelp rates the interaction as minor. Indacaterol inhaled and Tacrolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tacrolimus prolongs the QT interval and high systemic exposure to beta-2 agonists like indacaterol can also affect QTc and lower potassium. The combination may increase arrhythmia risk, though inhaled doses give limited systemic exposure.
How serious is the interaction between Indacaterol inhaled and Tacrolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is required at usual doses. Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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