Drug interactions
Indacaterol inhaled + Voriconazole
Severity: Moderate
Indacaterol inhaled and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole prolongs the QT interval and indacaterol can have cardiovascular effects including QT prolongation at high exposure. Voriconazole may also modestly increase indacaterol exposure via CYP3A4 and P-gp inhibition.
What this interaction means in plain words
Indacaterol inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT effects and inhibition of CYP3A4 and P-glycoprotein clearance of indacaterol.
What to do
No dose change is typically required at recommended indacaterol doses; monitor for palpitations, tremor and hypokalemia, and obtain an ECG if symptomatic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Indacaterol inhaled and Voriconazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Indacaterol inhaled with Voriconazole?
MediHelp rates the interaction as moderate. Indacaterol inhaled and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole prolongs the QT interval and indacaterol can have cardiovascular effects including QT prolongation at high exposure. Voriconazole may also modestly increase indacaterol exposure via CYP3A4 and P-gp inhibition.
How serious is the interaction between Indacaterol inhaled and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is typically required at recommended indacaterol doses; monitor for palpitations, tremor and hypokalemia, and obtain an ECG if symptomatic.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
