Drug interactions
Indapamide + Liraglutide
Severity: Minor
Indapamide and Liraglutide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-type diuretics can reduce glucose tolerance and may modestly blunt the glucose-lowering effect of liraglutide. Glycemic control may worsen, particularly when the diuretic is started or its dose raised.
What this interaction means in plain words
Indapamide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Liraglutide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: diuretic-related hypokalemia and reduced insulin sensitivity or secretion oppose incretin-mediated glucose lowering.
What to do
Monitor blood glucose and HbA1c when indapamide is started, stopped or titrated. Keep potassium in the normal range and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Liraglutide
Frequently asked questions
Can I take Indapamide with Liraglutide?
MediHelp rates the interaction as minor. Indapamide and Liraglutide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide-type diuretics can reduce glucose tolerance and may modestly blunt the glucose-lowering effect of liraglutide. Glycemic control may worsen, particularly when the diuretic is started or its dose raised.
How serious is the interaction between Indapamide and Liraglutide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when indapamide is started, stopped or titrated. Keep potassium in the normal range and adjust antidiabetic therapy if needed.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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