Drug interactions
Indapamide + Macimorelin
Severity: Major
Indapamide and Macimorelin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin modestly prolongs the QT interval and indapamide can contribute via electrolyte disturbances. Combined use may increase the risk of torsade de pointes during testing.
What this interaction means in plain words
Indapamide and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Macimorelin belongs to Endocrine.
Why it happens
Additive QTc prolongation, with diuretic-induced hypokalemia.
What to do
Avoid macimorelin testing while on QT-prolonging drugs; where possible, withhold indapamide for an adequate washout before the test and verify electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Indapamide
Other interactions of Macimorelin
Frequently asked questions
Can I take Indapamide with Macimorelin?
MediHelp rates the interaction as major. Indapamide and Macimorelin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Macimorelin modestly prolongs the QT interval and indapamide can contribute via electrolyte disturbances. Combined use may increase the risk of torsade de pointes during testing.
How serious is the interaction between Indapamide and Macimorelin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid macimorelin testing while on QT-prolonging drugs; where possible, withhold indapamide for an adequate washout before the test and verify electrolytes.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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