Drug interactions
Indapamide + Magnesium hydroxide
Severity: Minor
Indapamide and Magnesium hydroxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide, a thiazide-like diuretic, can increase urinary magnesium loss and lower serum magnesium with chronic use. Intermittent magnesium hydroxide is unlikely to be meaningfully affected.
What this interaction means in plain words
Indapamide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Magnesium hydroxide belongs to Gastrointestinal Tract.
Why it happens
Thiazide-like diuretics increase renal magnesium excretion by reducing distal tubular reabsorption.
What to do
No routine action is required. Monitor serum magnesium during long-term indapamide therapy and replace if low.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium hydroxide
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Magnesium hydroxide?
MediHelp rates the interaction as minor. Indapamide and Magnesium hydroxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide, a thiazide-like diuretic, can increase urinary magnesium loss and lower serum magnesium with chronic use. Intermittent magnesium hydroxide is unlikely to be meaningfully affected.
How serious is the interaction between Indapamide and Magnesium hydroxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is required. Monitor serum magnesium during long-term indapamide therapy and replace if low.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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