Drug interactions
Indapamide + Magnesium oxide
Severity: Minor
Indapamide and Magnesium oxide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide increases urinary magnesium loss and can cause hypomagnesemia with long-term use. Magnesium supplementation may offset this effect, so this is more a therapeutic consideration than a harmful interaction.
What this interaction means in plain words
Indapamide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Indapamide belongs to Cardiovascular; Magnesium oxide belongs to Gastrointestinal Tract.
Why it happens
Indapamide promotes renal magnesium excretion, lowering serum magnesium.
What to do
Monitor serum magnesium during long-term indapamide therapy and supplement if deficient.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indapamide
Other interactions of Magnesium oxide
- Chloroquine + Magnesium oxide Moderate
- Ciprofloxacin + Magnesium oxide Moderate
- Dolutegravir + Magnesium oxide Moderate
- Doxycycline + Magnesium oxide Moderate
- Eltrombopag + Magnesium oxide Moderate
- Gemifloxacin + Magnesium oxide Moderate
Frequently asked questions
Can I take Indapamide with Magnesium oxide?
MediHelp rates the interaction as minor. Indapamide and Magnesium oxide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Indapamide increases urinary magnesium loss and can cause hypomagnesemia with long-term use. Magnesium supplementation may offset this effect, so this is more a therapeutic consideration than a harmful interaction.
How serious is the interaction between Indapamide and Magnesium oxide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during long-term indapamide therapy and supplement if deficient.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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