Drug interactions
Indapamide + Mefloquine
Severity: Major
Indapamide and Mefloquine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indapamide can cause hypokalemia and hypomagnesemia and has itself been associated with QT prolongation, which may amplify the QT effect of mefloquine. This raises the risk of torsades de pointes.
What this interaction means in plain words
Indapamide and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Indapamide belongs to Cardiovascular; Mefloquine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation, worsened by diuretic-induced electrolyte depletion.
What to do
Check potassium and magnesium before and during co-therapy and replace as needed. Obtain an ECG, and consider another antimalarial or antihypertensive if risk factors are present.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mefloquine
- Arsenic trioxide + Mefloquine Contraindicated
- Dronedarone + Mefloquine Contraindicated
- Ibutilide + Mefloquine Contraindicated
- Levoketoconazole + Mefloquine Contraindicated
- Mefloquine + Nilotinib Contraindicated
- Mefloquine + Pimozide Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Mefloquine?
MediHelp rates the interaction as major. Indapamide and Mefloquine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Indapamide can cause hypokalemia and hypomagnesemia and has itself been associated with QT prolongation, which may amplify the QT effect of mefloquine. This raises the risk of torsades de pointes.
How serious is the interaction between Indapamide and Mefloquine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during co-therapy and replace as needed. Obtain an ECG, and consider another antimalarial or antihypertensive if risk factors are present.
What other medicines interact with Mefloquine?
MediHelp also lists interactions of Mefloquine with, for example, Arsenic trioxide, Dronedarone, Ibutilide. The full list is on the Mefloquine page.
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