Drug interactions
Indapamide + Osimertinib
Severity: Moderate
Indapamide and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QTc interval, and indapamide may add to this through electrolyte disturbance, mainly hypokalemia and hypomagnesemia. This increases the risk of torsades de pointes in susceptible patients.
What this interaction means in plain words
Indapamide and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Osimertinib belongs to Oncology.
Why it happens
Additive QT prolongation, with diuretic-induced electrolyte depletion lowering the repolarization reserve.
What to do
Monitor ECG and serum potassium, magnesium and calcium periodically, and correct abnormalities before and during osimertinib therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Osimertinib
Frequently asked questions
Can I take Indapamide with Osimertinib?
MediHelp rates the interaction as moderate. Indapamide and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QTc interval, and indapamide may add to this through electrolyte disturbance, mainly hypokalemia and hypomagnesemia. This increases the risk of torsades de pointes in susceptible patients.
How serious is the interaction between Indapamide and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, magnesium and calcium periodically, and correct abnormalities before and during osimertinib therapy.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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