Drug interactions
Indapamide + Rilpivirine
Severity: Moderate
Indapamide and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine can prolong the QT interval at supratherapeutic doses, and indapamide may promote QT-related risk through hypokalemia and hypomagnesemia. The combination may increase the chance of torsades de pointes in predisposed patients.
What this interaction means in plain words
Indapamide and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT prolongation with diuretic-induced electrolyte depletion lowering the repolarization reserve.
What to do
Check and correct potassium and magnesium before and during therapy, and obtain an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Indapamide with Rilpivirine?
MediHelp rates the interaction as moderate. Indapamide and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine can prolong the QT interval at supratherapeutic doses, and indapamide may promote QT-related risk through hypokalemia and hypomagnesemia. The combination may increase the chance of torsades de pointes in predisposed patients.
How serious is the interaction between Indapamide and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before and during therapy, and obtain an ECG in patients with other QT risk factors.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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