Drug interactions
Indapamide + Tizanidine
Severity: Moderate
Indapamide and Tizanidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine lowers blood pressure centrally and indapamide adds vasodilatory and diuretic effects. Together they may cause additive hypotension and orthostatic dizziness.
What this interaction means in plain words
Indapamide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Tizanidine belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic hypotension from central sympatholytic action and thiazide-like diuresis and vasodilation.
What to do
Monitor blood pressure and orthostatic symptoms when starting or changing doses. Reduce the dose of either drug if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Tizanidine?
MediHelp rates the interaction as moderate. Indapamide and Tizanidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tizanidine lowers blood pressure centrally and indapamide adds vasodilatory and diuretic effects. Together they may cause additive hypotension and orthostatic dizziness.
How serious is the interaction between Indapamide and Tizanidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or changing doses. Reduce the dose of either drug if symptomatic hypotension occurs.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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