Drug interactions
Indapamide + Trimethoprim
Severity: Moderate
Indapamide and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim can cause hyperkalemia and hyponatremia, and has been linked with rare QT prolongation, while indapamide causes hyponatremia and hypokalemia. The combination can produce unpredictable electrolyte shifts and possible arrhythmia risk.
What this interaction means in plain words
Indapamide and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Overlapping electrolyte effects, particularly sodium, plus possible additive QT prolongation.
What to do
Monitor serum sodium and potassium within the first days to weeks of co-therapy, especially in elderly patients, and check an ECG if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Trimethoprim
Frequently asked questions
Can I take Indapamide with Trimethoprim?
MediHelp rates the interaction as moderate. Indapamide and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim can cause hyperkalemia and hyponatremia, and has been linked with rare QT prolongation, while indapamide causes hyponatremia and hypokalemia. The combination can produce unpredictable electrolyte shifts and possible arrhythmia risk.
How serious is the interaction between Indapamide and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium and potassium within the first days to weeks of co-therapy, especially in elderly patients, and check an ECG if other QT risk factors exist.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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