Drug interactions
Indapamide + Voriconazole
Severity: Moderate
Indapamide and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, and indapamide can cause hypokalemia and hypomagnesemia that further increase arrhythmia risk. Torsades de pointes may result.
What this interaction means in plain words
Indapamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Indapamide belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation, worsened by diuretic-induced electrolyte depletion.
What to do
Check and correct potassium and magnesium and monitor ECG during concurrent use; consider another antihypertensive if other QT risk factors exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Indapamide
Frequently asked questions
Can I take Indapamide with Voriconazole?
MediHelp rates the interaction as moderate. Indapamide and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are associated with QT prolongation, and indapamide can cause hypokalemia and hypomagnesemia that further increase arrhythmia risk. Torsades de pointes may result.
How serious is the interaction between Indapamide and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium and monitor ECG during concurrent use; consider another antihypertensive if other QT risk factors exist.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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